It may take more red wine than is safe to drink to make a dent in Alzheimer’s disease (AD); however, a component of red wine is worth investigating further.
Resveratrol is found in the skin of grapes, red wine, grape juice, cocoa, and some berries. Thirty years ago, health gurus talked about a glass of red wine a day might lower the risk of dementia.
https://www.webmd.com/heart-disease/resveratrol-supplements. Resveratrol is a polyphenol, more specifically, a stilbenoid. It is found in nature and the supplement section online or in your grocery store. Some of the resveratrol supplements contain extracts from the Polygonum cuspidatum – other extract resveratrol directly from red wine or red grapes.
Resveratrol has been hyped to treat a lot of health issues – inflammation. LDL, cancer, heart disease, diabetes, and Alzheimer’s disease. Sirtuins regulate cellular health but need NAD+ (nicotinamide adenine dinucleotide) to function. Extended fasting or low-calorie dieting increases the sirtuin levels in the body. However, NAD+ is increased at least five-fold in the presence of resveratrol.
Resveratrol and AD Clinical Trials
https://alzheimersnewstoday.com/resveratrol/. Scientists discovered that resveratrol decreased the number of beta-amyloid protein in laboratory studies. Beta-amyloid protein can form plaques in the brain and begin the process leading to AD. Results have been published in the journal Neurology in 2015, the Journal of Neuroinflammation in 2017, and more.
https://www.lifeextension.com/magazine/2012/3/how-resveratrol-combats-leading-causes-death. Beta-amyloid trigger inflammation and oxidative stress in the brain, particularly in the memory centers. Inflammation can damage neurons and other brain tissue. Resveratrol inhibits beta-amyloid toxicity and prevents a cascade and clumping of beta-amyloid plaques.
https://www.nutraingredients.com/Article/2020/04/08/Resveratrol-may-reverse-cognitive-ageing-by-ten-years. A clinical study, Resveratrol Supporting Healthy Aging in Women (RESHAW), stated that resveratrol improved cognitive performance.
Yes, things look incredibly positive for health in general for people using resveratrol. Many studies support the improvement in brain health, and some show effective action in countering the development and progression of Alzheimer’s disease.
More research is needed; however, resveratrol comes from natural foods, and, as such, is challenging to fund clinical trials to test and evaluate foods. In addition, the FDA tests drugs and supplements, not foods. As a supplement, resveratrol was approved by the FDA in 2009. It is safe when used taken in doses up to 1,500 mg daily.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295233/ states that resveratrol bioavailability in the human body is significantly increased in the presence of piperine (black pepper extract). Therefore, when buying resveratrol as a supplement, look at the label to ensure it contains piperine.
Live Longer & Enjoy Life! – Red O’Laughlin – RedOLaughlin.com