Exercise is a good way to activate autophagy. Fasting and quality sleep are two more.

Scientists know that stress, radiation, infection, inflammation, and diet affect our health and longevity. All diseases start at the cellular level with chronic low-level inflammation. Antioxidants do a decent job of controlling the exponential spread of free radical damage, but sometimes we do not cooperate with our lifestyle choices.

Cellular Trash Pickup

https://www.thecut.com/2019/04/what-is-autophagy.html Autophagy is the trash pickup system of our bodies. This natural recycling system separates good from evil and eliminates the garbage at the cellular level. Partial membranes, diseased and damaged cells, cellular components no longer functioning 100%, toxins, and more make up the litter and waste in our bodies.

The Standard American Diet inhibits autophagy. The cellular pruning system operates well when tissues, organs, and cells in the body respond to food deprivation – fasting.

Cellular debris leftover time can promote health problems, cause early aging, and increases the risk of obesity, diabetes, and cancers. Removing the rubbish promotes heart and skin health, boosts metabolism and energy, and offers neurodegenerative protection.

Scientists believe misfolded and incomplete proteins cause Alzheimer’s and Parkinson’s diseases. Autophagy is a system to eradicate non-functioning proteins. Stress, nutrition, lifestyle, and environment regulate the effectiveness of autophagy.

Autophagy Stimulation

https://www.centerforhealingneurology.com/2019/06/09/stimulate-autophagy/ Fasting quickly activates autophagy in the liver, fat, brain, and muscle tissues. Dietary choices, exercise, sleep, destressing are methods to turn on the autophagy processes. Supplements like green tea, turmeric, ginger, Ceylon cinnamon, ginseng, garlic, and certain mushrooms increase cellular elimination management.

Omega-6 fatty acids, bergamot, berberine, and resveratrol also activate the junk collectors. Piperine is black pepper extract and enhances the efficacy of turmeric (curcumin) and resveratrol exponentially. These two supplements are not readily bioavailable in the body. However, piperine is like a magic steroid making them super-available for our bodies to use.

Fasting and Autophagy

https://www.livestrong.com/article/13724912-autophagy-fasting/ Fasting kicks autophagy into a higher gear. Why? Because insulin, in response to eating, inhibits autophagy. Likewise, autophagy is restricted when IGF-1 (insulin-like growth factor) increases with protein intake.

Non-eating time allows the body to repair itself. Autophagy begins around twelve to sixteen hours for most people. Our bodies must shift from burning glucose to using ketones for energy. Ten to fourteen hours is required to change energy sources. Some people live on ketogenic diets to burn fat. Fasting is still necessary to turn on the autophagy switch.

Exercise and Autophagy

https://www.whitneyerd.com/2020/01/the-truth-about-autophagy.html Blood flow is key to many body functions. Oxygen is supplied to the organs and tissues and provides the highway by which detritus from autophagy leaves the crime scene. Through heat generation in the muscles and the oxidation during a workout, exercise stress triggers the cleanup process at a higher level and longer duration.

Exercising once a week or month is not enough to keep autophagy in compliance with the body’s needs. Daily exercise tweaks the autophagic system to routinely eliminate remnant dysfunctional components in the muscles within hours of accumulation.

Pull the plug on your computer, and you might have a total shutdown or a few hours of battery time available for operation. The muscles work the same way. By not exercising, fasting, etc., the body is pulling the plug on autophagy and allowing room for disease and aging to take center-stage.

Sleep and autophagy

https://www.cedars-sinai.org/blog/autophagy.html The body’s repair mechanism activates during sleep. Rest, good quality restorative sleep sparks both the glymphatic and autophagy systems. The glymphatic system empties litter and rubbish from the central nervous system like the lymphatic system does for the body.

Circadian rhythms maintain health. Eating and drinking before bedtime disrupt sleep quality and repair time for muscles and organs, especially the liver. When your sleep cycle aligns with your circadian rhythm, sleep protects autophagy cells from free radicals. Sleep becomes the antioxidant to preserve and protect the mechanism responsible for cleaning the body of unused, unwanted, and discarded components.


There are other factors to increase or activate autophagy. The ones listed above give you a good idea of options you must do to improve your health by getting rid of the awful stuff building up inside you daily.

I fast 72 hours monthly to reenergize my immune system. Autophagy is fully activated and working wonders after 24 hours of fasting.

Live Longer & Enjoy Life! – Red O’Laughlin – RedOLaughlin.com



4 Responses

  1. I woke up this morning to this on my phone screen. DIVINE INTERVENTION. Superior information. Thank you. Also consider this: 1) Look up the definition of “Mitosis”. 2) Then look up “The effect of caffeine on mitosis” Gerald Milligan

    1. Caffeine has a triggering effect on autophagy also. I chose to leave it out of this article. There were many other things that could have been added. Thanks for commenting. I really appreciated it.

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