Parkinson’s disease (PD) researchers are exploring many different options to tackle this uncurable disease. I mentioned several natural options in yesterday’s article, https://redolaughlin.com/understanding-alpha-synuclein-in-parkinsons-disease-molecular-insights-and-therapeutic-approaches/. Almost all involved inhibiting, destroying, or reducing the toxicity of alpha-synuclein, a protein inside brain neurons.
Parkinson’s Disease Treatment Research
https://www.apdaparkinson.org/article/new-parkinsons-treatment-in-clinical-trials-2023/. One promising option is increasing the activity of GLP-1 to inactivate immune cells in the brain. A few days ago, I wrote about how a weakened immune system may be a potential pathway for PD to progress: https://redolaughlin.com/the-immune-systems-surprising-connection-to-parkinsons-disease/.
When a PD patient has both a weakened immune system and a leaky blood-brain barrier (BBB), the risk of creating the opportunity for PD to develop and progress increases. Quality sleep, exercise, stress management, hydration, and several other factors can improve your immune system.
Similar lifestyle issues apply to the BBB; however, the brain requires a few more specific actions – avoiding alcohol, avoiding gluten, limiting sugar, increasing resveratrol, sulforaphane, and omega-3 fatty acids (and a few more) can make significant improvements with the health of your BBB.
There was mention of increasing GLP-1 (glucagon-like peptide 1) activity, but it applies primarily to those with type-II diabetes, and the results are not as great as expected. This sounds nice, but it is not worth the time unless you have both type II diabetes and PD. In that case, talk to your doctor.
Inflammation and oxidative stress are the causes of many diseases. PD is one of them. Inflammation and oxidative stress in the brain can be lowered. https://drwillcole.com/brain-health/how-to-reduce-brain-inflammation. Lifestyle changes that improve your health will improve your brain’s health and lower inflammation. Balanced nutrition, restricted calories, fasting, gut microbiome balance, healthy fats, reduced sugars, antioxidants, curcumin (with piperine – black pepper extract), fermented foods, mushrooms (those with high levels of polysaccharide β-glucans to enhance brain-derived neurotrophic factor (BDNF – Reishi, cordyceps, maitake, lion’s mane, turkey tail, shiitake, oyster, and others), stress management, quality sleep, and exercise are worth incorporating into your daily choices and activities.
Mitochondria function is critical for PD patients. Many health issues originate when mitochondria are not working normally. Dr. Axe has several great suggestions – https://draxe.com/health/mitochondria/. Caloric restriction by choice or through fasting increases the bioenergetic efficiency of mitochondria. Exercise forces the body to make more mitochondria and related enzymes.
Balanced nutrition and antioxidants provide defensive support to cellular health. Quality sleep and stress management are required to keep mitochondrial health high. NAD+ (nicotinamide adenine dinucleotide – a form of vitamin B3) is crucial for cellular and mitochondrial health.
Conclusion
I prefer to identify natural options for any health improvement. My research is for audience awareness and education. Adding additional supplements or deciding to do intermittent or extended fasting is something that must be discussed with your doctor, especially when you are under care and taking any prescribed medications.
This article’s source of data listed many other PD suggestions, related to prescription medications. That is not an area that I normally provide information about or recommend. I am not a physician nor medically trained. Talk to your physician and pharmacist for detailed information about potential actions.
Live Long & Enjoy Live! – Red O’Laughlin – RedOLaughin.com
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