Brain cell health keeps us functional well into our retirement

Immune System

https://en.wikipedia.org/wiki/Immune_system. Our immune system is our first line of defense against pathogens – viruses, bacteria, parasites, and fungi. Our parents’ immunities genetically give us an innate immune system at birth. The adaptive immune system is a tailored response to different pathogens we encounter in our lives. https://www.medicalnewstoday.com/articles/320101 provides great insight into the inner workings of our immune system.

Parkinson’s Disease and the Immune System

https://www.medicalnewstoday.com/articles/how-the-immune-system-contributes-to-parkinsons-disease. We expect our immune systems to protect us from foreign invaders. When our immune system is healthy, it works that way. A challenged or unhealthy immune system does not offer the same level of protection. It might create health problems.

Parkinson’s disease (PD) is a neurodegenerative disorder. Typical symptoms include tremors, uncoordinated muscle movement, shaking (hands, arms, jaw, head, etc.), rigidity or stiffness, balance/coordination issues, and more.

Many medical researchers believe that genes and the environment cause PD. PD progresses as brain cells (neurons) die. Initially, the loss is so gradual you may not even notice. The cause of neuron death is the topic of many studies.

Recently, some scientists think there may be a link between our immune system and PD. Why? When the immune system is not functioning correctly, it generates inflammation. Chronic low-level cellular inflammation is the cause of nearly every disease. The immune system is expected to prevent disease development as foreign molecules are created from mutations. When that does not happen, maybe the immune system is the cause or part of the cause.

PD & Age

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989046/. PD is a neurodegenerative disease second to Alzheimer’s disease. The immune system naturally degrades as we age. After 60 years of age, many processes in the body decline – hormone creation, bone density, cardiac output, cognitive function, and many more. Our immune system is no different.

The autoimmune response works well when we are healthy. However, is it possible for the immune system to mis-recognize a brain protein as an invader when the immune system is challenged? Maybe. We might get an immune response to a typical infection previously contained and eliminated by the immune response. A challenged immune system might not stop an invading cell from creating a home in our brain.

Blood-Brain Barrier (BBB) & Immune System

https://www.nature.com/articles/s41423-021-00757-x. The BBB protects the brain from foreign molecules. The BBB can be healthy or challenged, like every organ and system in our body. Some scientists think that a challenged immune system might allow invading cells to infiltrate the brain without protection and allow infection or disease to establish a foothold inside the brain.

When (or if) this happens, the brain accumulates non-functioning proteins and other impaired or abnormal cells. If the immune system is not responding correctly, the further development of neurodegenerative processes continues.

Autophagy & PD

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739982/#:~:text=Autophagy%2C%20as%20major%20intracellular%20machinery,disease%20and%20amyotrophic%20lateral%20sclerosis. Autophagy is the process by which our bodies clean out cells and recycle components that can be fixed and returned to normal function. Unfortunately, autophagy does not start until we stop eating for nearly a day.

At or around 16-20 hours, the autophagy process begins and reaches 100% around 70 hours of total fasting. Most of us never fast that long. I do a 72-hour fast monthly and have done so for years. Many times, the extended fast exceeds 100 hours and occasionally 200 hours.

I describe autophagy in my speeches as a garage truck entering our bloodstream and stopping at every cell. It picks up the garbage inside the cell and moves to the next cell. A recycle truck follows the garbage truck, identifies which components can be fixed and recycled, and performs that function. Non-repairable parts are eliminated. At the cellular level, the body cleans up the daily mess of cellular metabolism. People who never fast do not get the benefits of autophagy. Is this part of the process by which PD develops in our brain?

Motor Movement & PD

https://www.ncbi.nlm.nih.gov/books/NBK536995/. PD progresses along the motor movement pathway rather than cognitive decline. The part of the brain that controls motor movement is the substantial nigra. When PD is diagnosed, this part of the brain has the most damage. It is thought that a weakened BBB and challenged immune system might allow the immune system to identify the substantial nigra as a foreign invader. It sounds plausible.

Neurodegenerative disease does not happen overnight. It doesn’t happen in a few years. It takes many years for individual cells (neurons) to be swept away, and little by little, the overall function of an organ begins down a slippery slope, never returning to full function. Neuro-inflammation coupled with neurodegeneration sets the table for every aspect of dementia, including PD.

Controlling Inflammation in the Brain

https://www.nature.com/articles/s41392-023-01486-5. The brain is complex. Researchers have difficulty shutting down or enhancing one aspect of inflammatory signaling pathways. When perfected, this might be a major step in treating those with dementia. Some animal models are showing positive results. Limited success is limited but promising.

Is the cause more on the neuro-inflammation side or the neurodegenerative side? Scientists cannot say with certainty. Can pro-inflammatory molecules be replaced with anti-inflammatory ones? Can it be done before significant damage is done to neurons? Too many questions remain unanswered.

Conclusion

There is strong evidence that chronic low-level cellular inflammation is the genesis of disease. However, we are predisposed to believe our immune system protects us. Yet, when the immune system is not working as advertised, it can lead to another assumption. One that I had never thought about. When the immune system is not working for us, is it working against us? There is some very plausible work done to substantiate that possibility.

Add into that potential pathway a degradation in the BBB’s ability to protect the brain, and it seems that inflammation can get a stronghold inside the brain and begin its dirty work of creating havoc and neurodegeneration. Fortunately, the BBB and our immune system can improve with better gut health, avoiding gluten and sugar, increasing omega-3 fatty acids, getting longer-quality sleep, managing stress, and exercising. This is a short list. There are many more things that can help improve both your BBB and immune system.

Antioxidants fight inflammation. One food does not work against all types of inflammation. Include several types of leafy green vegetables, colored fruits and vegetables, and healthy fats in your daily regimen.

Live Longer & Enjoy Life! – Red O’Laughlin – RedOLaughlin.com

 

51 Responses

  1. Thank you I have just been searching for information approximately this topic for a while and yours is the best I have found out so far However what in regards to the bottom line Are you certain concerning the supply

  2. I liked it as much as you did. Even though the picture and writing are good, you’re looking forward to what comes next. If you defend this walk, it will be pretty much the same every time.

  3. Toolbox Hub appears to be a comprehensive online resource offering a wide array of tools designed to streamline and enhance various tasks for professionals, students, and everyday internet users. Its extensive suite of text tools, including generators for dummy text and legal documents, as well as converters and counters, provides essential assistance in content creation and editing. The image editing tools, from basic resizing to more complex conversions, make it an invaluable asset for graphic designers and photographers alike. Moreover, Toolbox Hub’s calculators cover an extensive range of needs from basic arithmetic to more specialized calculations like sales tax and loan estimations, appealing to a broad audience including individuals in finance and academia. The unit converter tools further extend its utility, offering quick and accurate conversions across various units, making it a go-to resource for engineers, scientists, and students. For the tech-savvy, the website offers a collection of binary and website management tools that can aid in coding, website optimization, and debugging. These features are particularly beneficial for developers and webmasters looking to enhance their site’s performance and user experience. Overall, Toolbox Hub positions itself as a versatile and powerful ally in the digital world, providing a multitude of tools under one roof to simplify complex tasks, enhance productivity, and foster creativity. Its intuitive design, coupled with the sheer variety of tools available, makes it an attractive option for anyone looking to optimize their digital tasks. Whether you’re drafting a document, editing an image, or calculating complex equations, Toolbox Hub seems equipped to provide the necessary tools for a wide array of tasks.

  4. The amount of affection that I had for you is indescribable. It does not matter how beautiful something is or how beautifully you have written it if you are only reading it quickly. It is my firm belief that you ought to give it another shot very soon. I am grateful that you have made certain that this hike is risk-free. I shall make an effort to go on it on multiple occasions.

  5. you are in reality a just right webmaster The site loading velocity is incredible It seems that you are doing any unique trick In addition The contents are masterwork you have performed a wonderful task on this topic

  6. I just could not leave your web site before suggesting that I really enjoyed the standard information a person supply to your visitors Is gonna be again steadily in order to check up on new posts

  7. I do not even know how I ended up here but I thought this post was great I dont know who you are but definitely youre going to a famous blogger if you arent already Cheers

  8. Its like you read my mind You appear to know so much about this like you wrote the book in it or something I think that you can do with a few pics to drive the message home a little bit but instead of that this is excellent blog A fantastic read Ill certainly be back

  9. Excellent blog here Also your website loads up very fast What web host are you using Can I get your affiliate link to your host I wish my web site loaded up as quickly as yours lol

  10. I loved even more than you will get done right here. The picture is nice, and your writing is stylish, but you seem to be rushing through it, and I think you should give it again soon. I’ll probably do that again and again if you protect this hike.

  11. I loved as much as you will receive carried out right here The sketch is tasteful your authored subject matter stylish nonetheless you command get got an edginess over that you wish be delivering the following unwell unquestionably come further formerly again as exactly the same nearly very often inside case you shield this hike

  12. hello!,I really like your writing so a lot! share we keep up a correspondence extra approximately your post on AOL? I need an expert in this house to unravel my problem. May be that is you! Taking a look ahead to see you.

  13. I have been browsing online more than three hours today yet I never found any interesting article like yours It is pretty worth enough for me In my view if all website owners and bloggers made good content as you did the internet will be a lot more useful than ever before

  14. Simply desire to say your article is as surprising The clearness in your post is simply excellent and i could assume you are an expert on this subject Fine with your permission let me to grab your feed to keep up to date with forthcoming post Thanks a million and please carry on the gratifying work

  15. I do believe all the ideas youve presented for your post They are really convincing and will certainly work Nonetheless the posts are too short for novices May just you please lengthen them a little from subsequent time Thanks for the post

  16. Somebody essentially help to make significantly articles Id state This is the first time I frequented your web page and up to now I surprised with the research you made to make this actual post incredible Fantastic job

  17. Thanks I have recently been looking for info about this subject for a while and yours is the greatest I have discovered so far However what in regards to the bottom line Are you certain in regards to the supply

  18. Thanks I have recently been looking for info about this subject for a while and yours is the greatest I have discovered so far However what in regards to the bottom line Are you certain in regards to the supply

  19. obviously like your website but you need to test the spelling on quite a few of your posts Several of them are rife with spelling problems and I to find it very troublesome to inform the reality on the other hand Ill certainly come back again

  20. I do trust all the ideas youve presented in your post They are really convincing and will definitely work Nonetheless the posts are too short for newbies May just you please lengthen them a bit from next time Thank you for the post

  21. I just could not depart your web site prior to suggesting that I really loved the usual info an individual supply in your visitors Is gonna be back regularly to check up on new posts

  22. I was recommended this website by my cousin I am not sure whether this post is written by him as nobody else know such detailed about my trouble You are amazing Thanks

  23. I have been browsing online more than three hours today yet I never found any interesting article like yours It is pretty worth enough for me In my view if all website owners and bloggers made good content as you did the internet will be a lot more useful than ever before

  24. I wanted to express how wonderful your post is. I could tell you were an authority on the subject because of how obvious it was. If you don’t mind, I’d like to sign up for your RSS feed so I can receive updates whenever you publish new content. Many thanks, and please continue your enjoyable job.

  25. Its like you read my mind You appear to know a lot about this like you wrote the book in it or something I think that you could do with some pics to drive the message home a little bit but instead of that this is fantastic blog An excellent read I will certainly be back

  26. I loved as much as you will receive carried out right here The sketch is attractive your authored material stylish nonetheless you command get got an impatience over that you wish be delivering the following unwell unquestionably come more formerly again since exactly the same nearly a lot often inside case you shield this hike

  27. Hi I am so delighted I found your blog, I really found you by error, while I was looking on Bing for something else, Regardless I am here now and would just like to say kudos for a
    fantastic post and a all round exciting blog (I also love the theme/design), I don’t
    have time to go through it all at the minute but I have book-marked it and also added in your RSS feeds, so when I have time I will
    be back to read much more, Please do keep up the awesome
    work. I saw similar here: najlepszy sklep and also here: dobry sklep

  28. I find it incomprehensible that you are not more popular than you already are, given your intelligence. I was able to look at this topic from a number of angles because of your depth of knowledge. It appears that until a conversation turns to Woman gaga, neither men nor women seem to be really interested in things related to women. Continue your fantastic work.

  29. Hey there! Do you know if they make any plugins to assist with SEO?
    I’m trying to get my blog to rank for some targeted keywords but
    I’m not seeing very good gains. If you know of any please share.

    Thank you! You can read similar blog here: Najlepszy sklep

  30. Excellent blog here Also your website loads up very fast What web host are you using Can I get your affiliate link to your host I wish my web site loaded up as quickly as yours lol

  31. I wanted to express how wonderful your post is. I could tell you are an authority on this subject because of how obvious it is. If everything is up to you, I would want to follow your feed so I can be informed when you publish new content. Many thanks, and keep up the fantastic work.

  32. Your blog is a constant source of inspiration for me. Your passion for your subject matter is palpable, and it’s clear that you pour your heart and soul into every post. Keep up the incredible work!

Leave a Reply

Your email address will not be published. Required fields are marked *