Science magazine conducted a half-year study that may have been flawed. A new study looks for links between heart health and Alzheimer’s
The original 2006 study in Nature Magazine, https://www.nature.com/articles/nature04533, opined that the beta-amyloid protein subtype, Aβ*56, damages memory independently of plaques and neuronal loss.
The 2006 Study Flaws
https://www.science.org/doi/10.1126/science.1072994 Sylvain Lesné was the leading neuroscientist for the University of Minnesota, Twin Cities. Based on his findings, researchers have concentrated their explorations on finding cures that address the amyloid hypothesis as being the cause of Alzheimer’s disease (AD).
In the early ’90s, the amyloid hypothesis proposed that AD was caused by amyloid-beta peptides deposited as plaque. There were many theories regarding the cause(s) of AD, but the amyloid hypothesis was the most influential. It also offered a reasonable explanation for the formation of neurofibrillary tau tangles because of an imbalance between the production and the brain’s ability to clear the amyloid-beta peptides.
https://www.nbcnews.com/science/science-news/alzheimers-theory-undermined-accusations-fabricated-research-rcna39843. The current Nature Magazine study found that many items in the 2006 Study by Sylvain Lesné may not be accurate or have been manipulated. Over twenty papers by Lesné show more than seventy potentially tampered images were used to support his claim of the cause of AD.
As such, most of the research since 2006 has been focused on the amyloid beta protein forming sticky plaques in the brain. Several scientists have found that their testing did not support Sylvain Lesné’s theory that the Aβ*56, a subtype of the amyloid beta protein, is the primary cause of AD. Similarly, researchers have not been able to reproduce or validate the 2006 study results. One neuroscientist who coauthored the 2006 paper wants her name retracted from the study entirely.
https://www.nature.com/articles/nature04533 Our memory degrades with time. One current trend of thinking is that the amyloid beta protein can impair memory independent of plaque formation or neuronal degradation. In addition, some studies suggest that oxidative stress brought on by a high-carbohydrate diet (https://pubmed.ncbi.nlm.nih.gov/15082091/ and https://pubmed.ncbi.nlm.nih.gov/32506713/) might be more implicated in the cause of AD than previously suspected.
When you have used the wrong hypothesis to develop testing protocols and medicines, it is depressing to learn that a lot of time, talent, and money has been wasted. However, it may be that the amyloid beta protein is one pathway to AD and that some research has not been worthless.
I have written nearly four dozen articles on AD and presently collating those articles into a book. However, this data, along with some other exciting research I have done over the past month, needs to be presented so it can be captured in my book. One new theory by Dr. Berg looks most promising as a (or the) cause of AD.
Live Longer & Enjoy Life! – Red O’Laughlin – RedOLaughlin.com