Millions of doses of the COVID-19 vaccine are being produced.

Both Pfizer and Moderna use messenger RNA (mRNA) to deliver information to the immune system. The message carried describes the molecular structure of the SARS-CoV-2 virus that causes COVID-19.

When the spike of a coronavirus enters the host’s cell, the threat is recognized immediately. Our immune system begins a speedy attack and does not allow the virus to gain strength and infect our bodies.

Moderna’s mRNA Vaccine Last August, Moderna was given a contract ($1.5 billion) to develop a vaccine and manufacture 100 million doses to combat COVID-19. It was developed with help of the US Biomedical Advanced Research & Development Authority.

Moderna COVID-19 Vaccine Emergency Authorization Use Three days ago, the FDA issued an emergency use authorization (EAU) for Moderna’s mRNA vaccine for the prevention of COVID-19. Pfizer was issued the first EAU and Moderna the second EAU this month.

Both exhibit around 95% effectiveness with similar safety records. Potential benefits outweigh known and potential hazards. Pfizer’s vaccine is authorized for people 16 years and older while Moderna’s is restricted to 18 years and older.

Both mRNA vaccines target the spike of the coronavirus. The spike is the vehicle for the transmission of viral particles into our bodies. Our immune system recognizes the protein sequences in the spike and responds in force to shut down the attack. The spike does not create a health issue by itself.

What Differs Between Vaccines? The most obvious difference is the storage temperatures. Moderna’s vaccine can be stored in freezers found in many hospitals while the Pfizer vaccine requires significantly colder temperatures. The minus-75 degrees storage temperature for the Pfizer vaccine is fifty degrees colder than Moderna’s vaccine.

Pfizer’s logistics, distribution, and equipment are considerably more complicated. Moderna vaccines could be administered at local pharmacies whereas Pfizer’s vaccine would be restricted to larger hospital facilities.

Two 100-microgram doses given 28 days apart are required for Moderna’s vaccine. The Pfizer vaccine has two 30-microgram doses given 21 days apart. The 100-microgram dose was given to 15,000 study participants in clinical trials. Eleven people became infected with COVID-19 with no severe reactions and deaths. A saline solution used as a placebo for another control group had 185 catching the disease, 30 people developed severe cases, and one died.

All viruses contain fatty molecules. Moderna’s vaccine targets the spike glycoprotein. Components of the vaccine include tromethamine, tromethamine hydrochloride, acetic acid, sodium acetate, and sucrose. As such, scientists believe that this combination and approach is more flexible than Pfizer’s vaccine.

Both vaccines have similar safety records and demonstrated effectiveness. Additionally, both vaccines tend to have the same side effects. The most common side effects from Moderna’s vaccine are pain at the injection site, fatigue, headache, muscle and joint pain, chills, and swollen lymph nodes.

Side effects from both vaccines lasted 24-48 hours in almost all cases. Ten to fifteen percent of those getting inoculations are expected to show some side effects.

Shipments of Moderna’s vaccine are expected to leave the manufacturing facilities within a week. Pfizer distributed its vaccine to 636 locations. Moderna has plans to supply its vaccine to over 3,200 locations. Both vaccines are reserved for front-line workers and the elderly first. The window for general distribution across the United States is slated for late Spring and early Summer.


I have written and posted over 160 articles about COVID-19 this year. Many respondents have fears over the quickness of the clinical trials and the long-term safety of any messenger RNA vaccine.

There are many people restricted from receiving the mRNA vaccines due to pre-existing health conditions. Until herd immunity is effective and ongoing, the threat of contracting the coronavirus is real. Protect yourself and those who are unable to do so.

Live Longer & Enjoy Life! – Red O’Laughin –

8 Responses

  1. Red – Thanks for your concise and factual differentiation of the two vaccines. What additional products are in the pipeline and when might they be ready for distribution? Finally, what other countries or amalgamation of countries around the world are developing their own vaccines for use in their own regions?

    1. There are lots of things going on. Russia released its mRNA vaccine two weeks ago and is selling it around the world. AstraZenica has a vaccine that will be released shortly, but it is more of an immune booster than a vaccine.

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