Coronavirus molecules enter our bodies and spread. Within 24 hours, the virus has spread exponentially. We might be able to stop the virus from entering a cell, but it looks like an existing drug might be able to stop it from replicating and growing in our bodies
How many vaccines are going to be accepted by the public is unknown. The expedited research, development, and evaluation phases that normally take five to ten years have been compressed into months. This is phenomenal!
However, it does not engender safety in the minds of those who want to know how long the vaccine will last, the side effects, and the risk of death with those having pre-existing conditions. These unknowns are not worth the risk to many.
New Drug Option
https://www.medicalnewstoday.com/articles/drug-to-reduce-bleeding-could-treat-covid-19 Aprotinin is a drug that stops bleeding during surgery. A study was done at the Goethe University of Frankfurt, Germany recently tested the drug’s ability to stop the spread of SARS-CoV-2.
Aprotinin inhibits fibrinolysis, the breaking down of blood clots. It is used during surgery to reduce the risk of bleeding. It is hoped that aprotinin can prevent a mild case of COVID-19 from becoming a severe case by stopping the ability of the virus to spread.
https://www.mdpi.com/2073-4409/9/11/2377/htm The results of this study were published about three weeks ago in the journal Cells. The coronavirus spike connects with the host cell using the ACE2 (angiotensin-converting enzyme 2). The spike on the coronavirus cleaves and replicates using cellular proteases.
Aprotinin is a protease inhibitor and appears to disrupt the process of cleaving thereby stopping the replication and spread of the virus.
https://www.fda.gov/media/75969/download The data sheet for aprotinin can be found in this link. The side effects of aprotinin are atrial fibrillation, fever, nausea, low blood pressure, lung problems, kidney disease, blood clots, heart failure, anaphylaxis, trouble breathing, and stroke. It was removed from the marketplace in 2007. Aminocaproic acid and tranexamic acid are used today.
https://www.sciencedirect.com/science/article/abs/pii/S0166354211003858?via%3Dihub The mechanism by which aprotinin works has great potential to stop the spread of COVID-19 once it enters the body to be effective, the drug must be in an aerosol form. Currently, aprotinin is approved in aerosol form to treat influenza. Russia uses an aerosol form of aprotinin to treat influenza.
About one out of every three critically ill COVID-19 patients develop blood clots. Blood clots increase complications and significantly increase the risk of death.
Aprotinin is a promising, approved drug that can stop the formation of blood clots and prevents the replication process in the coronavirus. Side effects are well known and caused this drug to be withdrawn from the worldwide market.
Does an aerosol version provide the same side effects? It has been approved for influenza for its protease inhibition, not the fibrinolytic effects. Treatment in the nasal passages and lungs may not produce the same serious side effects.
Live Longer & Enjoy Life! – Red O’Laughlin – RedOLaughlin.com